This study investigated the influence of different dissolution methods on esomeprazole in-vitro release from mini-tablet coated with Eudragit L 100-55, aqueous acrylic enteric system. One of the methods utilized novel sinkers specifically designed to prevent mini-tablet from sticking to each other. This method produced the fastest and most reproducible drug release in buffer compared to USP 1 (baskets), USP 2 (paddles) or USP 2 with conventional sinkers.
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